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USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database


USC-OGP 2-DE database 
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Searching in 'USC-OGP 2-DE database' for entry matching: P05215




USC-OGP 2-DE database:  P05215


P05215


General information about the entry
View entry in simple text format
Entry nameTBA4A_HUMAN
Primary accession numberP68366
Secondary accession number(s) P05215
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Tubulin alpha-4A chain; AltName: Full=Alpha-tubulin 1; AltName: Full=Testis-specific alpha-tubulin; AltName: Full=Tubulin H2-alpha; AltName: Full=Tubulin alpha-1 chain;.
Gene nameName=TUBA4A
Synonyms=TUBA1
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

PLATELET_4-5 {PLATELET 4-5}
Homo sapiens (Human)
PLATELET_4-5
  map experimental info
 
PLATELET_4-5

MAP LOCATIONS:
pI=4.91; Mw=21047
pI=4.96; Mw=18897
pI=5.02; Mw=18707
pI=5.00; Mw=18211



PLATELET_4-7 {PLATELET 4-7}
Homo sapiens (Human)
PLATELET_4-7
  map experimental info
 
PLATELET_4-7

MAP LOCATIONS:
pI=5.08; Mw=51589
pI=5.06; Mw=51463



PLATELET_5-6 {PLATELET 5-6}
Homo sapiens (Human)
PLATELET_5-6
  map experimental info
 
PLATELET_5-6

MAP LOCATIONS:
pI=5.07; Mw=52994
pI=5.05; Mw=52731

Cross-references
UniProtKB/Swiss-ProtP68366; TBA4A_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry nameTBA4A_HUMAN
Primary accession numberP68366
Secondary accession number(s) A8MUB1 B3KNQ6 P05215
Sequence was last modified on August 13, 1987 (version 1)
Annotations were last modified on March 15, 2017 (version 141)
Name and origin of the protein
DescriptionRecName: Full=Tubulin alpha-4A chain; AltName: Full=Alpha-tubulin 1; AltName: Full=Testis-specific alpha-tubulin; AltName: Full=Tubulin H2-alpha; AltName: Full=Tubulin alpha-1 chain;
Gene nameName=TUBA4A
Synonyms=TUBA1
Encoded onName=TUBA4A; Synonyms=TUBA1
KeywordsAcetylation; Alternative splicing; Amyotrophic lateral sclerosis; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; GTP-binding; Methylation; Microtubule; Neurodegeneration; Nitration; Nucleotide-binding; Phosphoprotein; Reference proteome.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX06956; CAA30026.1; -; Genomic_DNA
EMBLBT006731; AAP35377.1; -; mRNA
EMBLAK054731; BAG51418.1; -; mRNA
EMBLAK299958; BAH13182.1; -; mRNA
EMBLAY895018; AAW65371.1; -; Genomic_DNA
EMBLAC068946; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLAC114803; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLCH471063; EAW70718.1; -; Genomic_DNA
EMBLCH471063; EAW70719.1; -; Genomic_DNA
EMBLBC009238; AAH09238.1; -; mRNA
CCDSCCDS2438.1; -. [P68366-1]; .
CCDSCCDS63131.1; -. [P68366-2]; .
PIRA25873; A25873; .
RefSeqNP_001265481.1; NM_001278552.1. [P68366-2]; .
RefSeqNP_005991.1; NM_006000.2. [P68366-1]; .
UniGeneHs.75318; -; .
ProteinModelPortalP68366; -; .
SMRP68366; -; .
BioGrid113128; 212; .
IntActP68366; 49; .
MINTMINT-1394538; -; .
STRING9606.ENSP00000248437; -; .
ChEMBLCHEMBL2095182; -; .
DrugBankDB06772; Cabazitaxel; .
DrugBankDB05147; CYT997; .
DrugBankDB03010; Epothilone B; .
DrugBankDB01873; Epothilone D; .
DrugBankDB01179; Podofilox; .
DrugBankDB05281; S-8184; .
DrugBankDB00541; Vincristine; .
iPTMnetP68366; -; .
PhosphoSitePlusP68366; -; .
SwissPalmP68366; -; .
DMDM55977476; -; .
DOSAC-COBS-2DPAGEP68366; -; .
OGPP05215; -; .
EPDP68366; -; .
MaxQBP68366; -; .
PaxDbP68366; -; .
PeptideAtlasP68366; -; .
PRIDEP68366; -; .
DNASU7277; -; .
EnsemblENST00000248437; ENSP00000248437; ENSG00000127824. [P68366-1]; .
EnsemblENST00000392088; ENSP00000375938; ENSG00000127824. [P68366-2]; .
GeneID7277; -; .
KEGGhsa:7277; -; .
UCSCuc002vkt.3; human. [P68366-1]; .
CTD7277; -; .
DisGeNET7277; -; .
GeneCardsTUBA4A; -; .
HGNCHGNC:12407; TUBA4A; .
HPACAB004621; -; .
HPACAB005887; -; .
HPAHPA039247; -; .
HPAHPA043684; -; .
HPAHPA063394; -; .
MalaCardsTUBA4A; -; .
MIM191110; gene; .
MIM616208; phenotype; .
neXtProtNX_P68366; -; .
OpenTargetsENSG00000127824; -; .
PharmGKBPA162407391; -; .
eggNOGKOG1376; Eukaryota; .
eggNOGCOG5023; LUCA; .
GeneTreeENSGT00760000119060; -; .
HOGENOMHOG000165711; -; .
HOVERGENHBG000089; -; .
InParanoidP68366; -; .
KOK07374; -; .
OMASEGREDM; -; .
OrthoDBEOG091G0736; -; .
PhylomeDBP68366; -; .
TreeFamTF300314; -; .
ReactomeR-HSA-114608; Platelet degranulation; .
ReactomeR-HSA-1445148; Translocation of GLUT4 to the plasma membrane; .
ReactomeR-HSA-190840; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; .
ReactomeR-HSA-190861; Gap junction assembly; .
ReactomeR-HSA-2132295; MHC class II antigen presentation; .
ReactomeR-HSA-2467813; Separation of Sister Chromatids; .
ReactomeR-HSA-2500257; Resolution of Sister Chromatid Cohesion; .
ReactomeR-HSA-2565942; Regulation of PLK1 Activity at G2/M Transition; .
ReactomeR-HSA-380259; Loss of Nlp from mitotic centrosomes; .
ReactomeR-HSA-380270; Recruitment of mitotic centrosome proteins and complexes; .
ReactomeR-HSA-380284; Loss of proteins required for interphase microtubule organization from the centrosome; .
ReactomeR-HSA-380320; Recruitment of NuMA to mitotic centrosomes; .
ReactomeR-HSA-389957; Prefoldin mediated transfer of substrate to CCT/TriC; .
ReactomeR-HSA-389960; Formation of tubulin folding intermediates by CCT/TriC; .
ReactomeR-HSA-389977; Post-chaperonin tubulin folding pathway; .
ReactomeR-HSA-437239; Recycling pathway of L1; .
ReactomeR-HSA-5610787; Hedgehog 'off' state; .
ReactomeR-HSA-5617833; Cilium Assembly; .
ReactomeR-HSA-5620912; Anchoring of the basal body to the plasma membrane; .
ReactomeR-HSA-5620924; Intraflagellar transport; .
ReactomeR-HSA-5626467; RHO GTPases activate IQGAPs; .
ReactomeR-HSA-5663220; RHO GTPases Activate Formins; .
ReactomeR-HSA-6807878; COPI-mediated anterograde transport; .
ReactomeR-HSA-6811434; COPI-dependent Golgi-to-ER retrograde traffic; .
ReactomeR-HSA-6811436; COPI-independent Golgi-to-ER retrograde traffic; .
ReactomeR-HSA-68877; Mitotic Prometaphase; .
ReactomeR-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint; .
ReactomeR-HSA-8854518; AURKA Activation by TPX2; .
ReactomeR-HSA-983189; Kinesins; .
SIGNORP68366; -; .
ChiTaRSTUBA4A; human; .
GeneWikiTUBA4A; -; .
GenomeRNAi7277; -; .
PMAP-CutDBP68366; -; .
PROPR:P68366; -; .
ProteomesUP000005640; Chromosome 2; .
BgeeENSG00000127824; -; .
CleanExHS_TUBA4A; -; .
ExpressionAtlasP68366; baseline and differential; .
GenevisibleP68366; HS; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0070062; C:extracellular exosome; IDA:UniProtKB; .
GOGO:0005576; C:extracellular region; TAS:Reactome; .
GOGO:0005874; C:microtubule; IDA:UniProtKB; .
GOGO:0015630; C:microtubule cytoskeleton; IDA:HPA; .
GOGO:0005525; F:GTP binding; IEA:UniProtKB-KW; .
GOGO:0003924; F:GTPase activity; IEA:InterPro; .
GOGO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro; .
GOGO:0097711; P:ciliary basal body docking; TAS:Reactome; .
GOGO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome; .
GOGO:0007017; P:microtubule-based process; IEA:InterPro; .
GOGO:0002576; P:platelet degranulation; TAS:Reactome; .
Gene3D1.10.287.600; -; 1; .
Gene3D3.30.1330.20; -; 1; .
Gene3D3.40.50.1440; -; 1; .
InterProIPR002452; Alpha_tubulin; .
InterProIPR008280; Tub_FtsZ_C; .
InterProIPR000217; Tubulin; .
InterProIPR018316; Tubulin/FtsZ_2-layer-sand-dom; .
InterProIPR023123; Tubulin_C; .
InterProIPR017975; Tubulin_CS; .
InterProIPR003008; Tubulin_FtsZ_GTPase; .
PANTHERPTHR11588; PTHR11588; 1; .
PfamPF00091; Tubulin; 1; .
PfamPF03953; Tubulin_C; 1; .
PRINTSPR01162; ALPHATUBULIN; .
PRINTSPR01161; TUBULIN; .
SMARTSM00864; Tubulin; 1; .
SMARTSM00865; Tubulin_C; 1; .
SUPFAMSSF52490; SSF52490; 1; .
SUPFAMSSF55307; SSF55307; 1; .
PROSITEPS00227; TUBULIN; 1; .



USC-OGP 2-DE database image


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Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

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